We have taken part in public engagement activities such as participating in Pint of Science. Our group runs regular blood pressure awareness days in Bristol and businesses and in public spaces helping over 500 people to “Know their BP number”. In collaboration with groups in Poland and St Bartholomew’s Hospital in London we have demonstrated that carotid body modulation is a potential treatment option for resistant hypertension and heart failure. We have translated the basic science work of Professor Julian Paton on carotid body dysfunction. Our group has pioneered the mechanistic understanding of the role of carotid body in contributing to sympathetic activation in hypertension.
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Baroreflex sensitivity and heart rate variability.This is a way of directly recording sympathetic nerve activity that is directed towards blood vessels supplying skeletal muscle.The main techniques that are in use in our lab are: Our clinical physiology lab is run by Dr Emma Hart at the Clinical Research Imaging Centre in Bristol. Exercise training and cardiac rehabilitation.
Investigating novel molecules to block P2X3 receptors.What are the mechanisms contributing to drug resistant hypertension?.Imaging to identify novel targets such as cerebral vascular anomalies.Role of carotid body to drive sympathetic activation.Why do young people develop high blood pressure?.The key questions that we are trying to address focus on the role the sympathetic nervous system in hypertension and heart failure: To investigate mechanisms involved in the development of hypertension and transition to heart failure and so develop novel therapies to improve outcomes for patients.
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